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The Rise of COX-2 Inhibitors in Veterinary Pain Management
A Historical Perspective

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The Rise of COX-2 Inhibitors in Veterinary Pain Management For much of the twentieth century, veterinary medicine operated in a dark age of pain management—where animals were believed to feel less than humans, where "nature's splint" justified surgical agony, and where the only drugs available burned holes in stomachs and shut down kidneys. *The Rise of COX-2 Inhibitors in Veterinary Pain Management* tells the gripping story of how a single biochemical discovery—distinguishing COX-1 from COX-2—shattered that paradigm, igniting a revolution that transformed clinics, curricula, and the very definition of animal welfare.

From the laboratory breakthroughs that promised selectivity to the species-specific minefields that turned canine miracles into feline fatalities, this book pulls back the curtain on the high-stakes translation of human pharmacology into veterinary practice. Witness the regulatory gauntlets, the commercial boom that brought carprofen and meloxicam to every exam room, and the post-marketing shockwaves—idiosyncratic liver failure, the Vioxx recall's chilling ripple effect, and the hard-won birth of modern pharmacovigilance. It is a saga of science colliding with biology, commerce, and ethics on the operating table.

Yet the narrative doesn't end at the pill bottle. Follow the revolution into the stall, the aviary, and the zoo; into the perioperative suite where preemptive analgesia rewrote surgical outcomes; and into the consulting room where client education became as vital as the prescription pad. Culminating in the arrival of EP4 antagonists and monoclonal antibodies, this definitive history reveals how a class of drugs did more than relieve suffering—it forced a profession to finally see, measure, and honor the pain it had long ignored.

Table of Contents:
  • Introduction
  • Chapter 1 The Landscape of Animal Pain: Early Veterinary Analgesia
  • Chapter 2 The Prostaglandin Paradigm: Early Nonsteroidal Anti-Inflammatory Drugs
  • Chapter 3 The Breakthrough Discovery: Distinguishing COX-1 and COX-2
  • Chapter 4 From Human Medicine to Comparative Biology: The Promise of Selectivity
  • Chapter 5 Molecular Targets and Cellular Mechanisms in Domestic Species
  • Chapter 6 Early Laboratory Trials: Measuring Efficacy and Gastric Sparing
  • Chapter 7 The Pioneer: Carprofen and the New Wave of Canine Therapies
  • Chapter 8 Navigating the Approval Pathway: Veterinary Regulatory Frameworks
  • Chapter 9 The Feline Dilemma: Pharmacokinetics, Toxicity, and Early Reluctance
  • Chapter 10 Meloxicam’s Emergence: Redefining Chronic Pain in Companion Animals
  • Chapter 11 The Commercial Boom: Marketing Modern Analgesia to the Profession
  • Chapter 12 Target Animal Safety Studies: Reading the Pre-Approval Data
  • Chapter 13 The Post-Marketing Shock: Adverse Event Reporting and Real-World Use
  • Chapter 14 The Human Vioxx Recall and Its Ripple Effects on Veterinary Medicine
  • Chapter 15 Coxibs Enter the Clinic: Deracoxib and Firocoxib Development
  • Chapter 16 Equine Applications: Managing Lameness and Navicular Syndrome
  • Chapter 17 Renal, Hepatic, and Cardiovascular Controversies in Practice
  • Chapter 18 Transforming Perioperative Protocols: Preemptive Surgical Pain Control
  • Chapter 19 Long-Term Geriatric Care: Osteoarthritis and Quality-of-Life Metrics
  • Chapter 20 Off-Label Realities: Exotic, Avian, and Zoo Animal Pain Management
  • Chapter 21 The Client Education Revolution: Teaching Pet Owners to Monitor Risk
  • Chapter 22 Shifting Veterinary Curricula: Institutionalizing Pain Assessment
  • Chapter 23 The Introduction of EP4 Receptor Antagonists: Beyond Traditional Inhibition
  • Chapter 24 Monoclonal Antibodies and the Expanding Landscape of Pain Therapeutics
  • Chapter 25 Retrospective and Legacy: How COX-2 Inhibitors Redefined Animal Welfare
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Author:

Vincent K. Ross

Published By:

MixCache.com Extended Catalog

Type:

Nonfiction

Date Published:

September 11, 2026

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